DNA binding properties of DAPI (4',6-diamidino-2-phenylindole) analogs having an imidazoline ring or a tetrahydropyrimidine ring: Groove-binding and intercalation | Zendy

Yukio Kubota | Zendy; Kenji Kubota | Zendy; Seiji Tani | Zendy

Open Access

DNA binding properties of DAPI (4',6-diamidino-2-phenylindole) analogs having an imidazoline ring or a tetrahydropyrimidine ring: Groove-binding and intercalation

Author(s) -

Yukio Kubota,

Kenji Kubota,

Seiji Tani

Publication year - 2000

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/44.1.53

Subject(s) - dapi , intercalation (chemistry) , dna , ring (chemistry) , circular dichroism , chemistry , fluorescence , stereochemistry , crystallography , biochemistry , organic chemistry , apoptosis , physics , quantum mechanics

DAPI analogs containing an imidazoline ring or a tetrahydropyrimidine ring have been synthesized to study DNA binding properties. Spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements indicate that DAPI analogs interact with DNA both by intercalation and by groove binding. The solution structures of complexes between DAPI analog and DNA oligomers have been characterized by proton NMR spectroscopy.

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