The synthesis of pyrrole(Py)/imidazole(lm) polyamide CPI conjugates which possess DNA interstrand cross-linking activity | Zendy

Tetsuya Bando | Zendy; Hideo Lida | Zendy; Isao Saito | Zendy; Hiroshi Sugiyama | Zendy

Open Access

The synthesis of pyrrole(Py)/imidazole(lm) polyamide CPI conjugates which possess DNA interstrand cross-linking activity

Author(s) -

Tetsuya Bando,

Hideo Lida,

Isao Saito,

Hiroshi Sugiyama

Publication year - 2000

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/44.1.45

Subject(s) - dimer , covalent bond , linker , chemistry , dna , conjugate , imidazole , polyamide , molecule , gel electrophoresis , combinatorial chemistry , pyrrole , polyacrylamide gel electrophoresis , stereochemistry , polymer chemistry , biochemistry , organic chemistry , enzyme , operating system , mathematical analysis , mathematics , computer science

Covalent dimers of ImPyLDu86 with various linkers were synthesized and their DNA interstrand cross-linking abilities were examined. Denaturing polyacrylamide gel electrophoresis indicated that dimer molecule with tetramethylene linker efficiently produced interstrand cross-link only in the presence of appropriate partner PyIm triamides.

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