Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine | Zendy

Toru Sugiyama | Zendy; Atsushi Kittaka | Zendy; Hiromitsu Takayama | Zendy; Michiko Tomioka | Zendy; Yoshiteru Ida | Zendy; Reiko Kuroda | Zendy

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Interaction of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2'-deoxyuridine

Author(s) -

Toru Sugiyama,

Atsushi Kittaka,

Hiromitsu Takayama,

Michiko Tomioka,

Yoshiteru Ida,

Reiko Kuroda

Publication year - 2000

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/44.1.41

Subject(s) - oligonucleotide , residue (chemistry) , lysine , dna , chemistry , peptide , oligopeptide , stereochemistry , amino acid residue , deoxyuridine , amino acid , biochemistry , combinatorial chemistry , peptide sequence , gene

We report the first example of chemical cross-linking of 5-formyl-2'-deoxyuridine containing oligonucleotides with oligopeptides through a Schiff base formation. Twenty amino acid residue peptides investigated here were derived from the DNA binding site of RecA protein. We have demonstrated that the lysine residue placed at the 6th or 8th position from the N-terminus of the peptide directly contacts with DNA.

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