Open AccessNO induced novel DNA lesions: Formation mechanism
Author(s) -
Masaki Yamada,
Toshinori Suzuki,
K Kanaori,
Kayoko Tajima,
Takashi Morii,
Kenji Makino
Publication year - 2000
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/44.1.273
Subject(s) - deoxyguanosine , 8 hydroxy 2' deoxyguanosine , chemistry , mechanism (biology) , dna , high performance liquid chromatography , lesion , chromatography , biochemistry , dna damage , dna oxidation , medicine , pathology , philosophy , epistemology
2'-Deoxyguanosine was treated with NO/O2 mixture at pH 7.0-7.8, and as well as the known major products such as 2'-deoxyxanthosine and 2'-deoxyoxanosine, some unidentified products were detected by RP-HPLC. In the present study, one of them has been characterized as a novel lesion, N2-nitro-2'-deoxyguanosine by spectrometric and chromatographic analysis. The mechanism for the production is also discussed.
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