Open AccessSynthesis of 2,3-dihydroinosine derivatives by reduction using BH3-THF
Author(s) -
Kosaku Hirota,
R Hattori,
Hironao Sajiki,
Y. Monguchi,
Osamu Muraoka,
Genzoh Tanabe
Publication year - 2000
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/44.1.113
Subject(s) - regioselectivity , chemistry , inosine , ring (chemistry) , combinatorial chemistry , reduction (mathematics) , purine , medicinal chemistry , organic chemistry , mathematics , enzyme , catalysis , geometry
A novel reductive method for the chemical modification of nucleosides is described. Reaction of inosine derivatives with boran-THF resulted in the regioselective reduction of purine ring to afford the corresponding 2,3-dihydroinosine derivatives in moderate yields.
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