Open AccessSynthetic studies and properties of N-tert-butylaminoxyl nucleosides
Author(s) -
Masakazu Aso,
Tetsuya Kaneko,
Masaya Nakamura,
Y. Matsui,
N. Koga,
Hiroshi Suemune
Publication year - 2003
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/3.1.9
Subject(s) - chemistry , materials science
We synthesized 5-N-tert-butylhydroxylamino-2'-deoxyuridine (9b) via lithium-halogen exchange reaction of sodium salt of 5-iodo-2'-deoxyuridine (8b). This procedure was applicable to synthesis of the corresponding uridine (9a) and N-benzoyl cytidine (13). Obtained 9b was converted into stable aminoxyl (5a) by treatment with Ag2O to study its properties as a novel spin-labeled nucleoside.
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