Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted aarabinofuranosyluracils | Zendy

Hiroaki Ozaki | Zendy; Kiyoshi Nakajima | Zendy; Kenji Yajima | Zendy; Kaoru Tatsui | Zendy; Masayasu Kuwahara | Zendy; H. Sawai | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted aarabinofuranosyluracils

Author(s) -

Hiroaki Ozaki,

Kiyoshi Nakajima,

Kenji Yajima,

Kaoru Tatsui,

Masayasu Kuwahara,

H. Sawai

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.59

Subject(s) - duplex (building) , oligonucleotide , uracil , dna , chemistry , derivative (finance) , dna synthesis , stereochemistry , combinatorial chemistry , biochemistry , financial economics , economics

The oligodeoxyribonucleotides (ODN) containing C-2 and/or C-5 substituted arabinofuranosyluracils were synthesized by a post-synthetic modification method. The duplex stability of the ODN bearing isocytosine derivative with DNA was lower than that of the normal ODN/DNA duplex but the ODN bearing C5-substituted uracil derivative was similar to the normal ODN/DNA duplex.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research