Open AccessPalladium-catalyzed H-D exchange into nucleic acids in deuterium oxide
Author(s) -
Hironao Sajiki,
F. Y. Aoki,
Hiroki Esaki,
Tomohiro Maegawa,
Kosaku Hirota
Publication year - 2003
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/3.1.55
Subject(s) - nucleic acid , deuterium , moiety , catalysis , palladium , chemistry , hydrogen–deuterium exchange , base (topology) , combinatorial chemistry , organic chemistry , hydrogen , biochemistry , physics , nuclear physics , mathematical analysis , mathematics
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleic acids. The results presented here provide a deuterium gas-free, totally catalytic and post-synthetic deuterium labeling method in D2O media.
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