Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase | Zendy

Yukio Kitade | Zendy; Hiroharu Kojima | Zendy; Fazila Zulfiqur | Zendy; Saori Yabe | Zendy; D. Yamagiwa | Zendy; Yasutomo Ito | Zendy; Masayuki Nakanishi | Zendy; Yoshihito Ueno | Zendy; Hei Sung Kim | Zendy; Yusuke Wataya | Zendy

Open Access

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase

Author(s) -

Yukio Kitade,

Hiroharu Kojima,

Fazila Zulfiqur,

Saori Yabe,

D. Yamagiwa,

Yasutomo Ito,

Masayuki Nakanishi,

Yoshihito Ueno,

Hei Sung Kim,

Yusuke Wataya

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.5

Subject(s) - plasmodium falciparum , hydrolase , inhibitory postsynaptic potential , recombinant dna , chemistry , stereochemistry , ic50 , biology , in vitro , biochemistry , enzyme , malaria , gene , immunology , neuroscience

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

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