Encapsulation of DNA with neutral glycocluster nanoparticles. A step toward artificial viruses | Zendy

Shinsuke Sando | Zendy; Taisuke Sasaki | Zendy; Y. AOYAMA | Zendy

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Encapsulation of DNA with neutral glycocluster nanoparticles. A step toward artificial viruses

Author(s) -

Shinsuke Sando,

Taisuke Sasaki,

Y. AOYAMA

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.289

Subject(s) - nanoparticle , encapsulation (networking) , dna , transfection , macromolecule , nanotechnology , artificial cell , biophysics , cytotoxicity , chemistry , materials science , biology , cell culture , genetics , biochemistry , computer science , in vitro , membrane , computer network

Number and size-controlled macromolecular associations are common in biology with viruses as a typical example. We report here a novel example of artificial viruses, in which the double-helical DNA is coated with 4-nm sized neutral glycocluster nanoparticles (GNPs). The resulting "glycoviruses" are compactly-packed, well charge-shielded (zeta approximately = 0 mV), and effectively transfect cell cultures without notable cytotoxicity.

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