Optimization of an ATP-binding ribonucleopeptide receptor | Zendy

Shinichi Sato | Zendy; Takeshi Hasegawa | Zendy; Masaki Hagihara | Zendy; M Fukuda | Zendy; Katsutoshi Ohkubo | Zendy; Takashi Morii | Zendy

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Optimization of an ATP-binding ribonucleopeptide receptor

Author(s) -

Shinichi Sato,

Takeshi Hasegawa,

Masaki Hagihara,

M Fukuda,

Katsutoshi Ohkubo,

Takashi Morii

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.239

Subject(s) - computational biology , selection (genetic algorithm) , binding selectivity , rna , protein subunit , chemistry , binding site , ligand (biochemistry) , domain (mathematical analysis) , receptor , biophysics , microbiology and biotechnology , biochemistry , biology , computer science , gene , mathematics , artificial intelligence , mathematical analysis

We describe here a new strategy for the selection and evolution of functional RNA-peptide complexes. An ATP-binding ribonucleopeptide was obtained by means of a structure-based design of ribonucleopeptide domain and by in vitro selection of the RNA subunit of the ribonucleopeptide. Approaches to optimize the ligand-binding selectivity of ribonucleopeptide will be discussed.

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