Open AccessHighly selective binding of metal ions to thymine-thymine and cytosine-cytosine base pairs in DNA duplexes
Author(s) -
Akira Ono,
Yoshihiro Miyake
Publication year - 2003
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/3.1.227
Subject(s) - thymine , cytosine , dna , nucleobase , metal ions in aqueous solution , chemistry , metal , base pair , stereochemistry , biochemistry , organic chemistry
Very specific binding of of Hg(II) and Ag(I) cations unexpectedly and significantly stabilizes the naturally occurring miss-base pairs, thymine-thymine and cytosine-cytosine, in DNA duplexes.
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