The octaplex structure of d(GCGAGAGC) with I-motif of guanine quartet, controlled by potassium concentration | Zendy

Jiro Kondo | Zendy; S. Umeda | Zendy; T. Sunami | Zendy; A. Takénaka | Zendy

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The octaplex structure of d(GCGAGAGC) with I-motif of guanine quartet, controlled by potassium concentration

Author(s) -

Jiro Kondo,

S. Umeda,

T. Sunami,

A. Takénaka

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.223

Subject(s) - histone octamer , guanine , dna , crystallography , motif (music) , molecule , chemistry , potassium , crystal structure , g quadruplex , stereochemistry , physics , biochemistry , nucleotide , nucleosome , gene , histone , organic chemistry , acoustics

Crystal structures of DNA octamer with the sequence d(GCGAGAGC) have been determined by X-ray analyses to investigate the specific DNA structural motifs that are useful for designing various functional DNA molecules. The octamers are assembled to form an octaplex with G-quartets and water-mediated A-quartets. At relatively high potassium concentration, however, the octaplex is split into two quadruplexes, each of which contains two G-duets. The two crystal forms suggest a dynamic formation of an octaplex from two quadruplexes in solution.

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