Beyond the Watson-Crick double helix: design of functional nucleic acids in silico, in tube, and in cell | Zendy

Naoki Sugimoto | Zendy

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Beyond the Watson-Crick double helix: design of functional nucleic acids in silico, in tube, and in cell

Author(s) -

Naoki Sugimoto

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.211

Subject(s) - nucleic acid , rna , molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , helix (gastropod) , nucleic acid structure , dna , in silico , watson , peptide nucleic acid , triple helix , chemistry , biology , biochemistry , stereochemistry , base pair , computer science , ecology , snail , natural language processing , gene

The structures and thermodynamic properties of non-Watson-Crick structures in RNA and DNA are described. The recent data on dangling ends in RNA, peptide nucleic acid (PNA), triplex, and G-quadruplex have resulted in an understanding of the catalysis, tertiary contact domains, and biological functions associated with these unpaired regions and special helices, and are useful in developing functional nucleic acids in cell.

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