Photochemical ligation of DNA "Words" for DNA computing | Zendy

N. Kishi | Zendy; Masayuki Ogino | Zendy; Isao Saito | Zendy; Y. Yoshimura | Zendy; Kiyoshi Fujimoto | Zendy

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Photochemical ligation of DNA "Words" for DNA computing

Author(s) -

N. Kishi,

Masayuki Ogino,

Isao Saito,

Y. Yoshimura,

Kiyoshi Fujimoto

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.183

Subject(s) - ligation , dna computing , dna , chemistry , photochemistry , computer science , biophysics , microbiology and biotechnology , biology , biochemistry

The photochemical DNA computing of 5-vinyluracil ((V)U) containing oligodeoxynucleotides (ODNs) tethered multiple "DNA words" is demonstrated. A new MARK and UNMARK operation based on the (V)U mediated reversible DNA photoligation has been developed for multiple-word DNA computing. The utility of this operation for DNA computing is demonstrated by solving a small Satisfiability problem (SAT problem) in which information was encoded in three tandem words.

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