DNA nanomotor using duplex-quadruplex conformational transition | Zendy

Kenichi Kanatani | Zendy; Yuta Ochi | Zendy; Akimitsu Okamoto | Zendy; Isao Saito | Zendy

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DNA nanomotor using duplex-quadruplex conformational transition

Author(s) -

Kenichi Kanatani,

Yuta Ochi,

Akimitsu Okamoto,

Isao Saito

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.161

Subject(s) - duplex (building) , g quadruplex , dna , fluorescence , chemistry , transition (genetics) , biophysics , conformational change , stereochemistry , crystallography , biology , biochemistry , physics , gene , quantum mechanics

For DNA nanomotor, we synthesized 8-Py-dG and incorporated it into d(T3G2)4 which can form quadruplex. We measured CD spectra for this ODN. The result suggested that this ODN was changed from quadruplex to duplex by the hybridization with the complementary strand. Further, this ODN had a very interesting property of fluorescence. The fluorescent intensity could be controlled whether the complementary strand was existed, or not.

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