Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions | Zendy

Fumi Nagatsugi | Zendy; Yasuhito Suenaga | Zendy; S. Sasaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Efficient cross-linking reactions by functional nucleobases capable of in situ activation under neutral conditions

Author(s) -

Fumi Nagatsugi,

Yasuhito Suenaga,

S. Sasaki

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.155

Subject(s) - cytidine , in situ , oligonucleotide , nucleobase , chemistry , duplex (building) , nucleoside , combinatorial chemistry , cytidine deaminase , biophysics , stereochemistry , biochemistry , dna , biology , enzyme , organic chemistry

We have previously described that the oligonucleotides containing phenylsulfide derivatives of 2-amino-6-vinylpurine nucleoside analog are activated within duplex to form cross-link toward cytidine selectively at the target site. However, the cross-linking reaction via the in-situ activation needs acidic conditions. In this paper, we wish to report that the new 2-amino-6-vinylpurine derivatives designed to have a structure of "double-activation" for in-situ activation exhibit fast cross-linking with cytidine under neutral conditions.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research