Synthesis of novel TFOs bearing an abasic portion and their triplex forming ability with a DNA duplex containing a pyrimidine-gapped polypurine strand | Zendy

Megumi Sato | Zendy; T. Moriguchi | Zendy; Kazuo Shinozuka | Zendy

Open Access

Synthesis of novel TFOs bearing an abasic portion and their triplex forming ability with a DNA duplex containing a pyrimidine-gapped polypurine strand

Author(s) -

Megumi Sato,

T. Moriguchi,

Kazuo Shinozuka

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.141

Subject(s) - phosphoramidite , pyrimidine , duplex (building) , triple helix , oligonucleotide , ap site , dna , chemistry , stereochemistry , reagent , combinatorial chemistry , biochemistry , dna damage , organic chemistry

Novel bi-functional anthraquinone phosphoramidite reagent was prepared from anthraquinolylethylenediamine and 2,2-bis(hydroxymethyl)propionic acid. The amidite reagent was incorporated into the middle position of oligoDNA consisting of pyrimidine residues, exclusively. The resulted oligoDNA was examined as the triple helix forming oligonucleotide (TFO) targeting a homopurine tract of a double helical DNA possessing a single pyrimidine-gap sequence.

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