Open AccessPhoto-regulation of DNA function by azobenzene-tethered oligonucleotides
Author(s) -
Hiroyuki Asanuma,
Daiki Matsunaga,
Mingsheng Liu,
Xingguo Liang,
Jiupeng Jhao,
Masaharu Komiyama
Publication year - 2003
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/3.1.117
Subject(s) - azobenzene , oligonucleotide , linker , dna , rnase h , chemistry , duplex (building) , dissociation (chemistry) , photochemistry , combinatorial chemistry , biophysics , rnase p , rna , molecule , biochemistry , biology , organic chemistry , computer science , gene , operating system
Multiple azobenzene moieties were tethered to DNA on D-threoninol linker, and formation and dissociation of DNA duplex could be reversibly photo-regulated either by irradiating UV or visible light. With this photo-responsive DNA, RNase H reaction was also successfully photo-regulated.
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