A new synthetic approach to cyclic bis(3'->5')diguanylic acid | Zendy

Rie Kawai | Zendy; Reiko Nagata | Zendy; Akiyoshi Hirata | Zendy; Yoshihiro Hayakawa | Zendy

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A new synthetic approach to cyclic bis(3'->5')diguanylic acid

Author(s) -

Rie Kawai,

Reiko Nagata,

Akiyoshi Hirata,

Yoshihiro Hayakawa

Publication year - 2003

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/3.1.103

Subject(s) - phosphoramidite , yield (engineering) , guanine , combinatorial chemistry , chemistry , biochemistry , nucleotide , materials science , dna , oligonucleotide , metallurgy , gene

We developed a novel synthesis of biologically important cyclic bis(3'-->5')diguanylic acid (cGpGp). The present synthesis includes two strategies different from those employed in an existing synthesis. They are the phosphoramidite method for the preparation of a guanylyl(3'-->5')guanylic acid intermediate and allyl protection for guanine bases and internucleotide linkages. These distinctive strategies have allowed the new synthesis to provide the target compound in a higher yield than that of the existing synthesis.

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