Design of intelligent nucleobases and DNA HOMO mapping | Zendy

Isao Saito | Zendy

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Design of intelligent nucleobases and DNA HOMO mapping

Author(s) -

Isao Saito

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.5

Subject(s) - nucleobase , guanine , dna , selectivity , chemistry , biophysics , gene , biology , biochemistry , nucleotide , catalysis

We have designed a new nucleobase, benzodeazaadenine (BDA) that has a stronger charge transport ability than guanine and is not destroyed during charge transport process. By incorporating this new nucleobase into DNA, we demonstrated a protocol for real DNA nano-wire that is far superior to natural DNA. We also demonstrated that the selectivity for the interaction of Mn(II) ion with guanine N7 in G runs is a HOMO-controlled process, and as a consequence, the selectivity for G-metal ion interactions obtained by 15N-NMR studies would directly reflect the HOMO distribution of G-containing sequences in B-DNA.

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