Mono(ADP-ribosyl)ation of DNA by apoptosis-inducing protein, pierisin | Zendy

Masahiko Watanabe | Zendy; Takeji TakamuraEnya | Zendy; T Kanazawa | Zendy; Yukari Totsuka | Zendy; Yuko MatsushimaHibiya | Zendy; K. Koyama | Zendy; Takashi Sügimura | Zendy; Keiji Wakabayashi | Zendy

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Mono(ADP-ribosyl)ation of DNA by apoptosis-inducing protein, pierisin

Author(s) -

Masahiko Watanabe,

Takeji TakamuraEnya,

T Kanazawa,

Yukari Totsuka,

Yuko MatsushimaHibiya,

K. Koyama,

Takashi Sügimura,

Keiji Wakabayashi

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.243

Subject(s) - apoptosis , dna , microbiology and biotechnology , chemistry , biology , biochemistry

The cabbage butterfly contains a potent cytotoxic protein, pierisin-1, and this protein is suggested to be an ADP-ribosylating toxin, Pierisin-1 effectively transferred an ADP-ribosyl group to DNA, but not to protein, as is the case with other bacteria-derived ADP-ribosylating toxins. Several spectral analyses and independent syntheses indicated that the acceptor site for ADP-ribosylation is N-2 of guanine base. Pierisin-1 induced apoptosis in mammalian cells accompanied by a release of cytochrome c and activation of a variety of caspases, and this apoptosis was inhibited by overexpression of Bcl-2. Pierisin-1 would be a novel DNA-damaging protein.

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