Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine | Zendy

Takako Hasegawa | Zendy; Masayuki Futagami | Zendy; Hei Sung Kim | Zendy; Akira Matsuda | Zendy; Yusuke Wataya | Zendy

Open Access

Analysis of single nucleotide polymorphisms in uridine/cytidine kinase gene encoding metabolic enzyme of 3'-ethynylcytidine

Author(s) -

Takako Hasegawa,

Masayuki Futagami,

Hei Sung Kim,

Akira Matsuda,

Yusuke Wataya

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.237

Subject(s) - exon , single nucleotide polymorphism , gene , intron , nucleotide , biology , cytidine , microbiology and biotechnology , genetics , uridine , enzyme , rna , biochemistry , genotype

We investigated single nucleotide polymorphisms (SNPs) in uck2 gene encoding metabolic enzyme of 3'-ethynylcytidine (ECyd) which were associated with drug response of ECyd, and the newly synthesized antitumor ribonucleoside analog. We analized that on exon-intron junction and exon region to affect the qualitative alteration of gene product directly in ECyd sensitive and resistant human cancer cell lines. As the results, cSNP and sSNP were detected in exon 4. In the promoter region, 3 SNPs were detected. Our data seem to be able to give an important knowledge, when ECyd is applied clinically.

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