Genomic analysis of mefloquine-resistant Plasmodium falciparum | Zendy

Khurshida Begum | Zendy; HeuiSoo Kim | Zendy; Y. Okuda | Zendy; Yusuke Wataya | Zendy; Masahiko Kimura | Zendy; T. Huruta | Zendy

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Genomic analysis of mefloquine-resistant Plasmodium falciparum

Author(s) -

Khurshida Begum,

HeuiSoo Kim,

Y. Okuda,

Yusuke Wataya,

Masahiko Kimura,

T. Huruta

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - Uncategorized

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.223

Subject(s) - mefloquine , halofantrine , plasmodium falciparum , clone (java method) , quinine , biology , artemisinin , gene , chloroquine , genetics , drug resistance , malaria , mutation , virology , immunology

We studied sequence polymorphism, expression level of pfmdr1 gene and drug sensitivity in mefloquine sensitive-strain as well as mefloquine-resistant clone/24 to understand underlying drug resistance mechanism. Mefloquine-resistant clone/24 exhibited decreased susceptibility to mefloquine, quinine, halofantrine and artemisinin and increased susceptibility to chloroquine. We analyzed sequence of pfmdr1 gene and found mutation in pfmdr1 on clone/24. Moreover, overexpression of mRNA level of pfmdr1 has been observed in mefloquine-resistant clone/24. Our results explain gene mutation and expression level of pfmdr1 may be associated in mefloquine resistance mechanism.

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