Role of 2'-OH on thermodynamic stability and structure of chimeric oligonucleotides | Zendy

T. Kanzaki | Zendy; Shuichi Nakano | Zendy; Naotoshi Sugimoto | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Role of 2'-OH on thermodynamic stability and structure of chimeric oligonucleotides

Author(s) -

T. Kanzaki,

Shuichi Nakano,

Naotoshi Sugimoto

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.189

Subject(s) - oligonucleotide , stability (learning theory) , chemical stability , chemistry , thermodynamics , computational biology , biophysics , materials science , dna , biology , physics , computer science , biochemistry , machine learning

Thermodynamic parameters of RNA/DNA chimeric duplexes were obtained systematically. Stability of the duplexes including chimeric junctions was context dependent, although CD spectra showed less structural perturbation by the junctions. Nearest-neighbor delta G degree 37 values for these chimeric RNA-DNA junctions suggested that 2'-OH on the 5'-side nucleotide at the junction may be the determinant for the nearest-neighbor stability of the chimeric junction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research