Development of electrochemically gene-analyzing method using DNA-modified electrodes | Zendy

Akimitsu Okamoto | Zendy; Kenichi Kanatani | Zendy; Isao Saito | Zendy

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Development of electrochemically gene-analyzing method using DNA-modified electrodes

Author(s) -

Akimitsu Okamoto,

Kenichi Kanatani,

Isao Saito

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.171

Subject(s) - differential pulse voltammetry , dna , electrochemistry , electrode , chemistry , redox , cyclic voltammetry , voltammetry , monolayer , dna sequencing , combinatorial chemistry , inorganic chemistry , biochemistry

For electrochemical DNA sequencing, several redox-responsive uridines modified at C5 were synthesized and site-specifically incorporated into DNA. Self-assembled DNA monolayers were prepared on a gold electrode using the dsDNA containing modified uridines. By measuring differential pulse voltammetry (DPV) using DNA-modified electrodes, the electrochemical response was strongly affected by the site of the redox-responsive uridine in dsDNA.

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