Control of photo-induced drug release by the use of conformational change of DNA | Zendy

Kazuhito Tanabe | Zendy; Takeshi Inasaki | Zendy; Akimitsu Okamoto | Zendy; Seiichi Nishimoto | Zendy; Isao Saito | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Control of photo-induced drug release by the use of conformational change of DNA

Author(s) -

Kazuhito Tanabe,

Takeshi Inasaki,

Akimitsu Okamoto,

Seiichi Nishimoto,

Isao Saito

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.167

Subject(s) - quenching (fluorescence) , chemistry , dna , intramolecular force , biotin , conformational change , biophysics , drug , naphthalene , photochemistry , combinatorial chemistry , stereochemistry , fluorescence , biochemistry , pharmacology , organic chemistry , biology , physics , quantum mechanics

Photo-induced drug release system which was controlled by triplet quenching using the molecular beacon strategy of photoreactive oligodeoxynucleotides (P-ODN) was developed. The strand ends of P-ODN were modified with a phenacyl ester of biotin and naphthalene as photoreactive group and triplet quencher, respectively. Photoirradiation to P-ODN in the presence of complementary DNA caused an efficient release of biotin. In contrast, the biotin release was suppressed in the absence of complementary DNA by the intramolecular triplet quenching in the stem-and-loop structure of P-ODN.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research