Anti-HIV-1 activity of L-DNA quadruplex | Zendy

Hidehito Urata | Zendy; Takashi Kumashiro | Zendy; T Otake | Zendy; Takuya Kawahata | Zendy; M. Akagi | Zendy

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Anti-HIV-1 activity of L-DNA quadruplex

Author(s) -

Hidehito Urata,

Takashi Kumashiro,

T Otake,

Takuya Kawahata,

M. Akagi

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.163

Subject(s) - human immunodeficiency virus (hiv) , dna , g quadruplex , computational biology , chemistry , virology , biology , biochemistry

Zintevir is a DNA 17mer that forms a quadruplex and shows strong anti-human immunodeficiency virus (HIV)-1 activity. The quadruplex formation is thought to be essential for the anti-HIV-1 activity of Zintevir. We synthesized the enantiomer of Zintevir and evaluated its structure and anti-HIV-1 activity. The results showed that the enantiomer has anti-HIV-1 activity comparable to that of Zintevir although it forms the mirror image quadruplex structure of Zintevir.

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