Modeling of a possible evolutional process from a ribozyme to a catalytic RNP | Zendy

Yoshiya Ikawa | Zendy; K. Tsuda | Zendy; Shigeyoshi Matsumura | Zendy; Shota Atsumi | Zendy; Takuro Inoue | Zendy

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Modeling of a possible evolutional process from a ribozyme to a catalytic RNP

Author(s) -

Yoshiya Ikawa,

K. Tsuda,

Shigeyoshi Matsumura,

Shota Atsumi,

Takuro Inoue

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.119

Subject(s) - ribozyme , rna , ligase ribozyme , tetrahymena , chemistry , rna world hypothesis , computational biology , microbiology and biotechnology , biology , biochemistry , gene

A model process for molecular evolution from an RNA enzyme to a catalytic RNA-protein complex (RNP) is proposed. In the model, one RNA-RNA interaction in the enzyme is replaced by an RNA-protein interaction via an intermediary state where the original RNA-RNA and newly introduced RNA-protein interaction co-exist. To test the model, a catalytic RNP was designed and examined by employing the Tetrahymena ribozyme.

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