Porphyrins and porphines inhibit the ribonuclease P reaction in vitro | Zendy

Yoshiki Hori | Zendy; Elena V. Bichenkova | Zendy; Alan N. Wilton | Zendy; Takashi Tanaka | Zendy; Kenneth T. Douglas | Zendy; Yo Kikuchi | Zendy

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Porphyrins and porphines inhibit the ribonuclease P reaction in vitro

Author(s) -

Yoshiki Hori,

Elena V. Bichenkova,

Alan N. Wilton,

Takashi Tanaka,

Kenneth T. Douglas,

Yo Kikuchi

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.111

Subject(s) - in vitro , ribonuclease , chemistry , biochemistry , rna , gene

Porphyrin has been reported to bind to the T psi C stem of tRNA. This site is also recognized by ribonuclease P, which is essential and ubiquitous endoribonuclease responsible for the maturation of 5' ends of tRNA precursors. Thus, we investigated the effects of porphyrins on the in vitro reaction of ribonuclease P from Escherichia coli. The results showed that some of porphyrins inhibited the reaction more strongly than any other inhibitors reported so far. In addition to the benzimidazole inhibition that we have previously reported, these unusual substrate-binding inhibitions may provide new leads for the novel anti-bacterial reagent design.

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