Study on the inhibition of protein production by L-cysteine derivatives of nucleic acid bases | Zendy

Yoshiaki Inaki | Zendy; Hisato Maruoka | Zendy

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Study on the inhibition of protein production by L-cysteine derivatives of nucleic acid bases

Author(s) -

Yoshiaki Inaki,

Hisato Maruoka

Publication year - 2002

Publication title -

nucleic acids symposium series

Language(s) - English

Resource type - Journals

eISSN - 1746-8272

pISSN - 0261-3166

DOI - 10.1093/nass/2.1.103

Subject(s) - nucleic acid , cysteine , in vivo , chemistry , biochemistry , amino acid , cell culture , blot , in vitro , protein biosynthesis , microbiology and biotechnology , gene , biology , enzyme , genetics

Isopoly (S-carboxymethyl-L-cysteine) derivatives of nucleic acids bases were prepared as antisense compounds. In previous studies, we investigated the properties of these compounds in vitro, and revealed that these compounds in vivo regulated the cell death presumably due to the inhibition of protein production. In this study, western and northern blots were carried out in order to reveal the mechanism of this inhibition for N-methyl-D-aspartate receptor in neuroblastoma x glioma hybrid NG108-15 cell line. In addition, we investigated the resistance of these compounds against cell extract and the metabolism. In conclusion, we proved that these compounds inhibited the protein production by antisense mechanism.

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