Open AccessX-ray analysis of d(GCGAACGC); Intra-duplex and inter-duplex hand-in-pocket motifs
Author(s) -
Jiro Kondo,
T. Sunami,
I. Hirao,
K.-i. Miura,
Atsushi Takenaka
Publication year - 2001
Publication title -
nucleic acids symposium series
Language(s) - English
Resource type - Journals
eISSN - 1746-8272
pISSN - 0261-3166
DOI - 10.1093/nass/1.1.199
Subject(s) - histone octamer , duplex (building) , dna , crystallography , molecule , a dna , structural motif , chemistry , computational biology , stereochemistry , biology , biochemistry , nucleosome , chromatin , organic chemistry
The structure of DNA octamer with the sequence d(GCGAACGC) has been determined by the X-ray crystallography to investigate the specific DNA structural motifs that are useful for designing various functional DNA molecules. Two kinds of interaction motifs for the bulged out adenosine residues have been found. One is an intra-duplex and the other is an inter-duplex hand-in-pocket motif. These interactions consist of the novel A:G pairs that have never been found so far in any crystal and solution studies on DNA molecules.
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