DANCER: a program for digital anatomical reconstruction of gene expression data | Zendy

Matti Kankainen | Zendy

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DANCER: a program for digital anatomical reconstruction of gene expression data

Author(s) -

Matti Kankainen

Publication year - 2003

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gng132

Subject(s) - biology , in situ hybridization , gene expression , microarray , expression (computer science) , computational biology , gene chip analysis , microarray analysis techniques , dna microarray , gene expression profiling , data set , gene , microarray databases , visualization , genetics , artificial intelligence , computer science , programming language

A digital anatomy construction (DANCER) program was developed for gene expression data. DANCER can be used to reconstruct anatomical images from in situ hybridization images, microarray or other gene expression data. The program fills regions of a drawn figure with the corresponding values from a gene expression data set. The output of the program presents the expression levels of a particular gene in a particular region relative to other regions. The program was tested with values from experimental in situ hybridization autoradiographs and from a microarray experiment. Reconstruction of in situ hybridization data from adult rat brain made by DANCER corresponded well with the original autoradiograph. Reconstruction of microarray data from adult mouse brains provided images that reflect actual expression levels. This program should help to provide visualization and interpretation of data derived from gene expression experiments. DANCER may be freely downloaded

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