Open AccessAPAatlas: decoding alternative polyadenylation across human tissues
Author(s) -
Hong Wei,
Hang Ruan,
Zhao Zhang,
Youqiong Ye,
Yaoming Liu,
Shengli Li,
Ying Jing,
Huiwen Zhang,
Lixia Diao,
Han Liang,
Leng Han
Publication year - 2019
Publication title -
nucleic acids research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkz876
Subject(s) - polyadenylation , biology , gene expression , gene , genetics , rna , computational biology , untranslated region , gene isoform , messenger rna , regulation of gene expression
Alternative polyadenylation (APA) is an RNA-processing mechanism on the 3' terminus that generates distinct isoforms of mRNAs and/or other RNA polymerase II transcripts with different 3'UTR lengths. Widespread APA affects post-transcriptional gene regulation in mRNA translation, stability, and localization, and exhibits strong tissue specificity. However, no existing database provides comprehensive information about APA events in a large number of human normal tissues. Using the RNA-seq data from the Genotype-Tissue Expression project, we systematically identified APA events from 9475 samples across 53 human tissues and examined their associations with multiple traits and gene expression across tissues. We further developed APAatlas, a user-friendly database (https://hanlab.uth.edu/apa/) for searching, browsing and downloading related information. APAatlas will help the biomedical research community elucidate the functions and mechanisms of APA events in human tissues.
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