MISIM v2.0: a web server for inferring microRNA functional similarity based on microRNA-disease associations | Zendy

Jianwei Li | Zendy; Shan Zhang | Zendy; Yanping Wan | Zendy; Yingshu Zhao | Zendy; Jiangcheng Shi | Zendy; Yuan Zhou | Zendy; Qinghua Cui | Zendy

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MISIM v2.0: a web server for inferring microRNA functional similarity based on microRNA-disease associations

Author(s) -

Jianwei Li,

Shan Zhang,

Yanping Wan,

Yingshu Zhao,

Jiangcheng Shi,

Yuan Zhou,

Qinghua Cui

Publication year - 2019

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkz328

Subject(s) - microrna , biology , web server , computational biology , disease , similarity (geometry) , rna , visualization , non coding rna , bioinformatics , genetics , the internet , gene , computer science , data mining , world wide web , artificial intelligence , pathology , image (mathematics) , medicine

MicroRNAs (miRNAs) are one class of important small non-coding RNA molecules and play critical roles in health and disease. Therefore, it is important and necessary to evaluate the functional relationship of miRNAs and then predict novel miRNA-disease associations. For this purpose, here we developed the updated web server MISIM (miRNA similarity) v2.0. Besides a 3-fold increase in data content compared with MISIM v1.0, MISIM v2.0 improved the original MISIM algorithm by implementing both positive and negative miRNA-disease associations. That is, the MISIM v2.0 scores could be positive or negative, whereas MISIM v1.0 only produced positive scores. Moreover, MISIM v2.0 achieved an algorithm for novel miRNA-disease prediction based on MISIM v2.0 scores. Finally, MISIM v2.0 provided network visualization and functional enrichment analysis for functionally paired miRNAs. The MISIM v2.0 web server is freely accessible at http://www.lirmed.com/misim/.

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