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1Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 2Translational Cancer Research Unit, Danish Cancer Society Research Center, Copenhagen, Denmark, 3Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark, 4Novo Nordisk Foundation Center for Protein Research, Department of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark and 5Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability