HMDD v3.0: a database for experimentally supported human microRNA–disease associations | Zendy

Zhou Huang | Zendy; Jiangcheng Shi | Zendy; Yuanxu Gao | Zendy; Chunmei Cui | Zendy; Shan Zhang | Zendy; Jianwei Li | Zendy; Yuan Zhou | Zendy; Qinghua Cui | Zendy

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HMDD v3.0: a database for experimentally supported human microRNA–disease associations

Author(s) -

Zhou Huang,

Jiangcheng Shi,

Yuanxu Gao,

Chunmei Cui,

Shan Zhang,

Jianwei Li,

Yuan Zhou,

Qinghua Cui

Publication year - 2018

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gky1010

Subject(s) - biology , microrna , human disease , database , disease , visualization , computational biology , bioinformatics , genetics , computer science , data mining , gene , medicine , pathology

Comprehensive databases of microRNA-disease associations are continuously demanded in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease Database (HMDD v3.0) manually collects a significant number of miRNA-disease association entries from literature. Comparing to HMDD v2.0, this new version contains 2-fold more entries. Besides, the associations have been more accurately classified based on literature-derived evidence code, which results in six generalized categories (genetics, epigenetics, target, circulation, tissue and other) covering 20 types of detailed evidence code. Furthermore, we added new functionalities like network visualization on the web interface. To exemplify the utility of the database, we compared the disease spectrum width of miRNAs (DSW) and the miRNA spectrum width of human diseases (MSW) between version 3.0 and 2.0 of HMDD. HMDD is freely accessible at http://www.cuilab.cn/hmdd. With accumulating evidence of miRNA-disease associations, HMDD database will keep on growing in the future.

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