Gene3D: Extensive prediction of globular domains in proteins | Zendy

Tony E. Lewis | Zendy; Ian Sillitoe | Zendy; Natalie L. Dawson | Zendy; Su Datt Lam | Zendy; Tristan Clarke | Zendy; David Lee | Zendy; Christine Orengo | Zendy; Jonathan Lees | Zendy

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Gene3D: Extensive prediction of globular domains in proteins

Author(s) -

Tony E. Lewis,

Ian Sillitoe,

Natalie L. Dawson,

Su Datt Lam,

Tristan Clarke,

David Lee,

Christine Orengo,

Jonathan Lees

Publication year - 2017

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkx1069

Subject(s) - domain (mathematical analysis) , context (archaeology) , biology , visualization , database , protein domain , sequence (biology) , computational biology , computer science , gene , genetics , data mining , mathematical analysis , paleontology , mathematics

Gene3D (http://gene3d.biochem.ucl.ac.uk) is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains. Amongst other updates, we have added visualization tools for exploring domain annotations in the context of other sequence features and in gene families. We also provide web-pages to visualize other domain families that co-occur with a given query domain family.

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