TFmiR: a web server for constructing and analyzing disease-specific transcription factor and miRNA co-regulatory networks | Zendy

Mohamed Hamed | Zendy; Christian Spaniol | Zendy; Maryam Nazarieh | Zendy; Volkhard Helms | Zendy

Open Access

TFmiR: a web server for constructing and analyzing disease-specific transcription factor and miRNA co-regulatory networks

Author(s) -

Mohamed Hamed,

Christian Spaniol,

Maryam Nazarieh,

Volkhard Helms

Publication year - 2015

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkv418

Subject(s) - biology , microrna , transcription factor , web server , computational biology , gene regulatory network , systems biology , gene , genetics , bioinformatics , world wide web , the internet , gene expression , computer science

TFmiR is a freely available web server for deep and integrative analysis of combinatorial regulatory interactions between transcription factors, microRNAs and target genes that are involved in disease pathogenesis. Since the inner workings of cells rely on the correct functioning of an enormously complex system of activating and repressing interactions that can be perturbed in many ways, TFmiR helps to better elucidate cellular mechanisms at the molecular level from a network perspective. The provided topological and functional analyses promote TFmiR as a reliable systems biology tool for researchers across the life science communities. TFmiR web server is accessible through the following URL: http://service.bioinformatik.uni-saarland.de/tfmir.

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