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COLOMBOS v3.0: leveraging gene expression compendia for cross-species analyses: Table 1.
Author(s) -
Marco Moretto,
Paolo Sonego,
Nicolas Dierckxsens,
Matteo Brilli,
Luca Bianco,
Daniela Ledezma-Tejeida,
Socorro GamaCastro,
Marco Galardini,
Chiara Romualdi,
Kris Laukens,
Julio ColladoVides,
Pieter Meysman,
Kristof Engelen
Publication year - 2015
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkv1251
Subject(s) - biology , annotation , expression (computer science) , table (database) , database , transcriptome , gene , information retrieval , computational biology , computer science , data mining , gene expression , bioinformatics , genetics , programming language
COLOMBOS is a database that integrates publicly available transcriptomics data for several prokaryotic model organisms. Compared to the previous version it has more than doubled in size, both in terms of species and data available. The manually curated condition annotation has been overhauled as well, giving more complete information about samples' experimental conditions and their differences. Functionality-wise cross-species analyses now enable users to analyse expression data for all species simultaneously, and identify candidate genes with evolutionary conserved expression behaviour. All the expression-based query tools have undergone a substantial improvement, overcoming the limit of enforced co-expression data retrieval and instead enabling the return of more complex patterns of expression behaviour. COLOMBOS is freely available through a web application at http://colombos.net/. The complete database is also accessible via REST API or downloadable as tab-delimited text files.

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