: a database of ciliate genome rearrangements | Zendy

J. C. Burns | Zendy; Denys Kukushkin | Zendy; Kelsi Lindblad | Zendy; Xiaohong Chen | Zendy; Natas̆a Jonoska | Zendy; Laura F. Landweber | Zendy

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<mds_ies_db>: a database of ciliate genome rearrangements

Author(s) -

J. C. Burns,

Denys Kukushkin,

Kelsi Lindblad,

Xiaohong Chen,

Natas̆a Jonoska,

Laura F. Landweber

Publication year - 2015

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkv1190

Subject(s) - biology , genome , ciliate , macronucleus , genetics , somatic cell , gene , germline , tetrahymena

Ciliated protists exhibit nuclear dimorphism through the presence of somatic macronuclei (MAC) and germline micronuclei (MIC). In some ciliates, DNA from precursor segments in the MIC genome rearranges to form transcriptionally active genes in the mature MAC genome, making these ciliates model organisms to study the process of somatic genome rearrangement. Similar broad scale, somatic rearrangement events occur in many eukaryotic cells and tumors. The <mds_ies_db> (http://oxytricha.princeton.edu/mds_ies_db) is a database of genome recombination and rearrangement annotations, and it provides tools for visualization and comparative analysis of precursor and product genomes. The database currently contains annotations for two completely sequenced ciliate genomes: Oxytricha trifallax and Tetrahymena thermophila.

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