Genome3D: exploiting structure to help users understand their sequences | Zendy

Tony E. Lewis | Zendy; Ian Sillitoe | Zendy; Antonina Andreeva | Zendy; Tom L. Blundell | Zendy; Daniel Buchan | Zendy; Cyrus Chothia | Zendy; Domenico Cozzetto | Zendy; Jose M Dana | Zendy; Ioannis Filippis | Zendy; Julian Gough | Zendy; David T. Jones | Zendy; Lawrence A. Kelley | Zendy; Gerard J. Kleywegt | Zendy; Federico Minneci | Zendy; Jaina Mistry | Zendy; Alexey G. Murzin | Zendy; Bernardo OchoaMontaño | Zendy; Matt E. Oates | Zendy; Marco Punta | Zendy; Owen J. L. Rackham | Zendy; Jonathan Stahlhacke | Zendy; Michael J.E. Sternberg | Zendy; Sameer Velankar | Zendy; Christine Orengo | Zendy

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Genome3D: exploiting structure to help users understand their sequences

Author(s) -

Tony E. Lewis,

Ian Sillitoe,

Antonina Andreeva,

Tom L. Blundell,

Daniel Buchan,

Cyrus Chothia,

Domenico Cozzetto,

Jose M Dana,

Ioannis Filippis,

Julian Gough,

David T. Jones,

Lawrence A. Kelley,

Gerard J. Kleywegt,

Federico Minneci,

Jaina Mistry,

Alexey G. Murzin,

Bernardo OchoaMontaño,

Matt E. Oates,

Marco Punta,

Owen J. L. Rackham,

Jonathan Stahlhacke,

Michael J.E. Sternberg,

Sameer Velankar,

Christine Orengo

Publication year - 2014

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gku973

Subject(s) - biology , resource (disambiguation) , set (abstract data type) , key (lock) , sequence (biology) , computational biology , domain (mathematical analysis) , interface (matter) , information retrieval , computer science , genetics , computer network , ecology , mathematical analysis , gibbs isotherm , pulmonary surfactant , mathematics , biochemistry , programming language

Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website to allow users to find Genome3D-annotated sequences similar to their own. We have improved and extended the Genome3D data, enlarging the source data set from three model organisms to 10, and adding VIVACE, a resource new to Genome3D. We have analysed and updated Genome3D's SCOP/CATH mapping. Finally, we have improved the superposition tools, which now give users a more powerful interface for investigating similarities and differences between structural models.

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