MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability | Zendy

Jie Li | Zendy; Ying Chen | Zendy; Xingliang Qin | Zendy; Jun-Zhi Wen | Zendy; Hongmei Ding | Zendy; Wei Xia | Zendy; Shaohua Li | Zendy; Xueting Su | Zendy; Wei Wang | Zendy; Hui Li | Zendy; Qiang Zhao | Zendy; Tao Fang | Zendy; LiangHu Qu | Zendy; Ningsheng Shao | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability

Author(s) -

Jie Li,

Ying Chen,

Xingliang Qin,

Jun-Zhi Wen,

Hongmei Ding,

Wei Xia,

Shaohua Li,

Xueting Su,

Wei Wang,

Hui Li,

Qiang Zhao,

Tao Fang,

LiangHu Qu,

Ningsheng Shao

Publication year - 2013

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkt839

Subject(s) - biology , hela , microrna , microbiology and biotechnology , nuclear export signal , rna interference , gene , cell nucleus , cell culture , rna , genetics , nucleus

MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist of ≈ 22 nt and are involved in several biological processes by regulating target gene expression. MiR-138 has many biological functions and is often downregulated in cancers. Our results showed that overexpression of miR-138 downregulated target RMND5A (required for meiotic nuclear division 5 homolog A) and reduced Exportin-5 stability, which results in decreased levels of pre-miRNA nuclear export in HeLa cells. We also found that miR-138 could significantly inhibit HeLa cell migration by targeting RMND5A. Our study therefore identifies miR-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research