SPACER: server for predicting allosteric communication and effects of regulation | Zendy

Alexander Goncearenco | Zendy; Simon Mitternacht | Zendy; Taipang Yong | Zendy; Birgit Eisenhaber | Zendy; Frank Eisenhaber | Zendy; Igor N. Berezovsky | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

SPACER: server for predicting allosteric communication and effects of regulation

Author(s) -

Alexander Goncearenco,

Simon Mitternacht,

Taipang Yong,

Birgit Eisenhaber,

Frank Eisenhaber,

Igor N. Berezovsky

Publication year - 2013

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkt460

Subject(s) - allosteric regulation , biology , function (biology) , effector , computational biology , computer science , genetics , microbiology and biotechnology , receptor

The SPACER server provides an interactive framework for exploring allosteric communication in proteins with different sizes, degrees of oligomerization and function. SPACER uses recently developed theoretical concepts based on the thermodynamic view of allostery. It proposes easily tractable and meaningful measures that allow users to analyze the effect of ligand binding on the intrinsic protein dynamics. The server shows potential allosteric sites and allows users to explore communication between the regulatory and functional sites. It is possible to explore, for instance, potential effector binding sites in a given structure as targets for allosteric drugs. As input, the server only requires a single structure. The server is freely available at http://allostery.bii.a-star.edu.sg/.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research