The Reactome pathway knowledgebase
Author(s) -
David Croft,
Antonio Fabregat,
Robin Haw,
M Orlic-Milacic,
Joel Weiser,
Guanming Wu,
Michael Caudy,
Phani Garapati,
Marc Gillespie,
Maulik R. Kamdar,
Bijay Jassal,
S Jupe,
Lisa Matthews,
Bruce May,
Stanislav Palatnik,
Karen Rothfels,
Veronica Shamovsky,
Heeyeon Song,
Mark Williams,
Ewan Birney,
Henning Hermjakob,
Lincoln Stein,
Peter D’Eustachio
Publication year - 2013
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkt1102
Subject(s) - biology , annotation , computational biology , proteome , human proteome project , human disease , computer science , bioinformatics , genetics , proteomics , gene
Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.
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