COLOMBOS v2.0: an ever expanding collection of bacterial expression compendia: Table 1.
Author(s) -
Pieter Meysman,
Paolo Sonego,
Luca Bianco,
Qiang Fu,
Daniela Ledezma-Tejeida,
Socorro GamaCastro,
Veerle Liebens,
Jan Michiels,
Kris Laukens,
Kathleen Marchal,
Julio ColladoVides,
Kristof Engelen
Publication year - 2013
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/gkt1086
Subject(s) - biology , computational biology , pipeline (software) , table (database) , database , dna microarray , visualization , robustness (evolution) , gene expression , gene , computer science , data mining , genetics , programming language
The COLOMBOS database (http://www.colombos.net) features comprehensive organism-specific cross-platform gene expression compendia of several bacterial model organisms and is supported by a fully interactive web portal and an extensive web API. COLOMBOS was originally published in PLoS One, and COLOMBOS v2.0 includes both an update of the expression data, by expanding the previously available compendia and by adding compendia for several new species, and an update of the surrounding functionality, with improved search and visualization options and novel tools for programmatic access to the database. The scope of the database has also been extended to incorporate RNA-seq data in our compendia by a dedicated analysis pipeline. We demonstrate the validity and robustness of this approach by comparing the same RNA samples measured in parallel using both microarrays and RNA-seq. As far as we know, COLOMBOS currently hosts the largest homogenized gene expression compendia available for seven bacterial model organisms.
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