Nucleic Acids Research: VOLUME 39 ISSUE 18 2011 | Zendy

J. R. Davie | Zendy; C. A. Saunders | Zendy; J. M. Walsh | Zendy; S. C. Weber | Zendy

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Nucleic Acids Research: VOLUME 39 ISSUE 18 2011

Author(s) -

J. R. Davie,

C. A. Saunders,

J. M. Walsh,

S. C. Weber

Publication year - 2011

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkr876

Subject(s) - biology , nucleic acid , computational biology , volume (thermodynamics) , genetics , quantum mechanics , physics

The content of the acetylated histone species associated with the highly transcriptionally active chromatin of yeast was examined. We found yeast chromatin to contain very high levels of the acetylated species for histones H3, H4 and possibly the H2B variants, H2B-1 and H2B-2. Sixty-three percent of the histone H4 species was represented by the di-, triand tetra-acetylated forms. These results make yeast chromatin among the most highly acetylated of any chromatins reported thus far. In addition, the results are consistent with the idea that hyperacetylation of histones allows chromatin to be transcribed at an increased rate.

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