ProSAT2--Protein Structure Annotation Server | Zendy

Razif R. Gabdoulline | Zendy; Susanne E. Ulbrich | Zendy; Stefan Richter | Zendy; Rebecca C. Wade | Zendy

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ProSAT2--Protein Structure Annotation Server

Author(s) -

Razif R. Gabdoulline,

Susanne E. Ulbrich,

Stefan Richter,

Rebecca C. Wade

Publication year - 2006

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkl216

Subject(s) - annotation , uniprot , visualization , biology , java , computer science , protein sequencing , computational biology , information retrieval , world wide web , bioinformatics , peptide sequence , genetics , data mining , programming language , gene

ProSAT2 is a server to facilitate interactive visualization of sequence-based, residue-specific annotations mapped onto 3D protein structures. As the successor of ProSAT (Protein Structure Annotation Tool), it includes its features for visualizing SwissProt and PROSITE functional annotations. Currently, the ProSAT2 server can perform automated mapping of information on variants and mutations from the UniProt KnowledgeBase and the BRENDA enzyme information system onto protein structures. It also accepts and maps user-prepared annotations. By means of an annotation selector, the user can interactively select and group residue-based information according to criteria such as whether a mutation affects enzyme activity. The visualization of the protein structures is based on the WebMol Java molecular viewer and permits simultaneous highlighting of annotated residues and viewing of the corresponding descriptive texts. ProSAT2 is available at http://projects.villa-bosch.de/mcm/database/prosat2/.

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