ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins | Zendy

Edouard de Castro | Zendy; Christian Sigrist | Zendy; Alexandre Gattiker | Zendy; V. Bulliard | Zendy; Petra Langendijk-Genevaux | Zendy; Elisabeth Gasteiger | Zendy; Amos Bairoch | Zendy; N. Hulo | Zendy

Open Access

ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

Author(s) -

Edouard de Castro,

Christian Sigrist,

Alexandre Gattiker,

V. Bulliard,

Petra Langendijk-Genevaux,

Elisabeth Gasteiger,

Amos Bairoch,

N. Hulo

Publication year - 2006

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkl124

Subject(s) - uniprot , biology , context (archaeology) , computational biology , representation (politics) , annotation , signature (topology) , feature (linguistics) , sequence alignment , computer science , bioinformatics , peptide sequence , genetics , gene , paleontology , linguistics , philosophy , geometry , mathematics , politics , political science , law

ScanProsite--http://www.expasy.org/tools/scanprosite/--is a new and improved version of the web-based tool for detecting PROSITE signature matches in protein sequences. For a number of PROSITE profiles, the tool now makes use of ProRules--context-dependent annotation templates--to detect functional and structural intra-domain residues. The detection of those features enhances the power of function prediction based on profiles. Both user-defined sequences and sequences from the UniProt Knowledgebase can be matched against custom patterns, or against PROSITE signatures. To improve response times, matches of sequences from UniProtKB against PROSITE signatures are now retrieved from a pre-computed match database. Several output modes are available including simple text views and a rich mode providing an interactive match and feature viewer with a graphical representation of results.

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