SMART 5: domains in the context of genomes and networks | Zendy

Ivica Letunić | Zendy

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SMART 5: domains in the context of genomes and networks

Author(s) -

Ivica Letunić

Publication year - 2005

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/gkj079

Subject(s) - biology , context (archaeology) , domain (mathematical analysis) , computational biology , genome , identification (biology) , annotation , protein domain , genomics , modular design , architecture domain , computer science , genetics , gene , programming language , software , mathematical analysis , paleontology , botany , mathematics , software architecture , enterprise architecture framework

The Simple Modular Architecture Research Tool (SMART) is an online resource (http://smart.embl.de/) used for protein domain identification and the analysis of protein domain architectures. Many new features were implemented to make SMART more accessible to scientists from different fields. The new 'Genomic' mode in SMART makes it easy to analyze domain architectures in completely sequenced genomes. Domain annotation has been updated with a detailed taxonomic breakdown and a prediction of the catalytic activity for 50 SMART domains is now available, based on the presence of essential amino acids. Furthermore, intrinsically disordered protein regions can be identified and displayed. The network context is now displayed in the results page for more than 350 000 proteins, enabling easy analyses of domain interactions.

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